Photonic crystal enhanced fluorescence for early breast cancer biomarker detection

Brian T. Cunningham, Richard C. Zangar

Research output: Contribution to journalReview article

Abstract

Photonic crystal surfaces offer a compelling platform for improving the sensitivity of surface-based fluorescent assays used in disease diagnostics. Through the complementary processes of photonic crystal enhanced excitation and enhanced extraction, a periodic dielectric-based nanostructured surface can simultaneously increase the electric field intensity experienced by surface-bound fluorophores and increase the collection efficiency of emitted fluorescent photons. Through the ability to inexpensively fabricate photonic crystal surfaces over substantial surface areas, they are amenable to single-use applications in biological sensing, such as disease biomarker detection in serum. In this review, we will describe the motivation for implementing high-sensitivity, multiplexed biomarker detection in the context of breast cancer diagnosis. We will summarize recent efforts to improve the detection limits of such assays though the use of photonic crystal surfaces. Reduction of detection limits is driven by low autofluorescent substrates for photonic crystal fabrication, and detection instruments that take advantage of their unique features.

Original languageEnglish (US)
Pages (from-to)617-628
Number of pages12
JournalJournal of Biophotonics
Volume5
Issue number8-9
DOIs
StatePublished - Aug 1 2012

Fingerprint

Optics and Photonics
biomarkers
Tumor Biomarkers
Photonic crystals
breast
Fluorescence
cancer
photonics
Breast Neoplasms
fluorescence
crystal surfaces
crystals
Limit of Detection
Biomarkers
Assays
Photons
Fluorophores
serums
platforms
Electric fields

Keywords

  • Biomarkers
  • Fluorescence enhancement
  • Nanostructured surface
  • Photonic crystal

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Photonic crystal enhanced fluorescence for early breast cancer biomarker detection. / Cunningham, Brian T.; Zangar, Richard C.

In: Journal of Biophotonics, Vol. 5, No. 8-9, 01.08.2012, p. 617-628.

Research output: Contribution to journalReview article

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