Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

Yanyu Xiong; Qinglan Huang; Taylor D. Canady; Priyash Barya; Shengyan Liu; Opeyemi H. Arogundade; Caitlin M. Race; Xiaojing Wang; Lifeng Zhou; Xing Wang; Manish Kohli; Andrew M. Smith; Brian T. Cunningham

Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

Yanyu Xiong, Qinglan Huang, Taylor D. Canady, Priyash Barya, Shengyan Liu, Opeyemi H. Arogundade, Caitlin M. Race, Xiaojing Wang, Lifeng Zhou, Xing Wang, Manish Kohli, Andrew M. Smith, Brian T. Cunningham

Research output: Contribution to journal › Conference article › peer-review

Abstract

We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

Original language	English (US)
Article number	JTh6A.2
Journal	Optics InfoBase Conference Papers
State	Published - 2022
Event	CLEO: Science and Innovations, S and I 2022 - San Jose, United States Duration: May 15 2022 → May 20 2022

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

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Xiong, Y., Huang, Q., Canady, T. D., Barya, P., Liu, S., Arogundade, O. H., Race, C. M., Wang, X., Zhou, L., Wang, X., Kohli, M., Smith, A. M., & Cunningham, B. T. (2022). Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers. Optics InfoBase Conference Papers, Article JTh6A.2.

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title = "Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers",

abstract = "We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.",

author = "Yanyu Xiong and Qinglan Huang and Canady, {Taylor D.} and Priyash Barya and Shengyan Liu and Arogundade, {Opeyemi H.} and Race, {Caitlin M.} and Xiaojing Wang and Lifeng Zhou and Xing Wang and Manish Kohli and Smith, {Andrew M.} and Cunningham, {Brian T.}",

note = "Publisher Copyright: {\textcopyright} Optica Publishing Group 2022, {\textcopyright} 2022 The Author(s); CLEO: Science and Innovations, S and I 2022 ; Conference date: 15-05-2022 Through 20-05-2022",

year = "2022",

language = "English (US)",

journal = "Optics InfoBase Conference Papers",

issn = "2162-2701",

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TY - JOUR

T1 - Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

AU - Xiong, Yanyu

AU - Huang, Qinglan

AU - Canady, Taylor D.

AU - Barya, Priyash

AU - Liu, Shengyan

AU - Arogundade, Opeyemi H.

AU - Race, Caitlin M.

AU - Wang, Xiaojing

AU - Zhou, Lifeng

AU - Wang, Xing

AU - Kohli, Manish

AU - Smith, Andrew M.

AU - Cunningham, Brian T.

PY - 2022

Y1 - 2022

N2 - We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

AB - We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

UR - http://www.scopus.com/inward/record.url?scp=85136789326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85136789326&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:85136789326

SN - 2162-2701

JO - Optics InfoBase Conference Papers

JF - Optics InfoBase Conference Papers

M1 - JTh6A.2

T2 - CLEO: Science and Innovations, S and I 2022

Y2 - 15 May 2022 through 20 May 2022

ER -

Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

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