Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

Yanyu Xiong, Qinglan Huang, Taylor D. Canady, Priyash Barya, Shengyan Liu, Opeyemi H. Arogundade, Caitlin M. Race, Xiaojing Wang, Lifeng Zhou, Xing Wang, Manish Kohli, Andrew M. Smith, Brian T. Cunningham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report 3, 000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

Original languageEnglish (US)
Title of host publication2022 Conference on Lasers and Electro-Optics, CLEO 2022 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781957171050
StatePublished - 2022
Event2022 Conference on Lasers and Electro-Optics, CLEO 2022 - San Jose, United States
Duration: May 15 2022May 20 2022

Publication series

Name2022 Conference on Lasers and Electro-Optics, CLEO 2022 - Proceedings

Conference

Conference2022 Conference on Lasers and Electro-Optics, CLEO 2022
Country/TerritoryUnited States
CitySan Jose
Period5/15/225/20/22

ASJC Scopus subject areas

  • Instrumentation
  • Spectroscopy
  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Management, Monitoring, Policy and Law
  • Materials Science (miscellaneous)
  • Acoustics and Ultrasonics
  • Atomic and Molecular Physics, and Optics

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