Photochemical cleavage of leader peptides

Noah Bindman, Remco Merkx, Robert Koehler, Nicholas Herrman, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review

Abstract

We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(i)-catalyzed alkyne-azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.

Original languageEnglish (US)
Pages (from-to)8935-8937
Number of pages3
JournalChemical Communications
Volume46
Issue number47
DOIs
StatePublished - Dec 21 2010

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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