Abstract
Imaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), such as catalytic nucleic acids and aptamers, have emerged as effective sensors for a wide range of molecules, photocaged control of these FNAs has played a key role in translating them into bioimaging agents with high spatiotemporal control. In this review, we summarize methods and results of photocaged FNAs based on photolabile modifications, photoisomerization, and photothermal activation. Future directions, including strategies to improve the performance of these photocaged FNAs, are also described.
Original language | English (US) |
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Pages (from-to) | 95-104 |
Number of pages | 10 |
Journal | Current Opinion in Chemical Biology |
Volume | 57 |
DOIs | |
State | Published - Aug 2020 |
Keywords
- Aptamers
- Bioimaging
- Biosensing
- DNAzymes
- Photocage
- Spatiotemporal control
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry