Photobleaching and intermittency localization microscopy

Paul D Simonson (Inventor), Paul R Selvin (Inventor)

Research output: Patent


A method of image analysis creates super-resolution images from images with high densities of fluorophores by processing a movie in which the fluorescent molecules or particles are photobleaching or blinking. The method looks for the individual photobleaching events that can be located with high resolution (nm to tens of nanometers scale). The positions of the photobleaching or blinking events are then drawn in a composite image that is at a much higher resolution than the original fluorescence movie.
Original languageEnglish (US)
U.S. patent number8445867
Filing date2/22/11
StatePublished - May 21 2013


Dive into the research topics of 'Photobleaching and intermittency localization microscopy'. Together they form a unique fingerprint.

Cite this