Photoacoustic microscopy and computed tomography: From bench to bedside

Lihong V. Wang, Liang Gao

Research output: Contribution to journalReview articlepeer-review


Photoacoustic imaging (PAI) of biological tissue has seen immense growth in the past decade, providing unprecedented spatial resolution and functional information at depths in the optical diffusive regime. PAI uniquely combines the advantages of optical excitation and those of acoustic detection. The hybrid imaging modality features high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth. Here we first summarize the fundamental principles underpinning the technology, then highlight its practical implementation, and finally discuss recent advances toward clinical translation.

Original languageEnglish (US)
Pages (from-to)155-185
Number of pages31
JournalAnnual Review of Biomedical Engineering
StatePublished - Jul 2014
Externally publishedYes


  • biomedical imaging
  • cancer diagnosis
  • human imaging
  • label-free imaging
  • small-animal imaging

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering


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