Photoacoustic computed tomography without accurate ultrasonic transducer responses

Qiwei Sheng, Kun Wang, Jun Xia, Liren Zhu, Lihong V. Wang, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging. When the imaging system employs conventional piezoelectric ultrasonic transducers, the ideal photoacoustic (PA) signals are degraded by the transducers' acousto-electric impulse responses (EIRs) during the measurement process. If unaccounted for, this can degrade the accuracy of the reconstructed image. In principle, the effect of the EIRs on the measured PA signals can be ameliorated via deconvolution; images can be reconstructed subsequently by application of a reconstruction method that assumes an idealized EIR. Alternatively, the effect of the EIR can be incorporated into an imaging model and implicitly compensated for during reconstruction. In either case, the efficacy of the correction can be limited by errors in the assumed EIRs. In this work, a joint optimization approach to PACT image reconstruction is proposed for mitigating errors in reconstructed images that are caused by use of an inaccurate EIR. A variable projection method is employed to refine the measured EIR during the process of reconstructing the sought-after absorbed optical energy density. Computer-simulation and experimental studies are conducted to investigate the numerical properties of the method and demonstrate its value for mitigating image distortions and enhancing the visibility of fine structures.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2015
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781628414134
StatePublished - Jan 1 2015
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States
Duration: Feb 8 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotons Plus Ultrasound: Imaging and Sensing 2015
CountryUnited States
CitySan Francisco

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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