Phosphonic acid compounds and screening method

William W Metcalf (Inventor), Kou-San Ju (Inventor), Jiangtao Gao (Inventor), James R Doroghazi (Inventor), Wilfred (Willem) A van der Donk (Inventor)

Research output: Patent


The present invention relates to pharmaceutical compositions comprising a phosphonic acid compound, such as a natural product. Such compounds can include, such as an antibiotic or compound with other activity, derived from an Actinobacteria strain having a gene encoding pepM (phosphoenolpyruvate phosphomutase) or a pepM-dependent biosynthetic pathway. The present invention also relates to methods for treating or preventing or reducing the risk of a bacterial infection by administering a therapeutically effective or prophylactically effective amount of a phosphonic acid antibiotic, or a pharmaceutical composition containing such an antibiotic, to a patient or subject in need thereof. The present invention further relates to methods for isolating, purfying, and identifying such phosphonic acid compounds from Actinobacteria strains.
Original languageEnglish (US)
U.S. patent number9993490
StatePublished - Jun 12 2018


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