The highly thermodynamically favorable oxidation of phosphite to phosphate by phosphite dehydrogenase (PtxD) makes the enzyme useful for cofactor regeneration (see figure). Deuterium exchange in D2O provides labeled phosphite for the preparation of deuterated products.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Sep 2 2002|
- Enzyme catalysis
- Isotopic labeling
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