Phosphite dehydrogenase: A versatile cofactor-regeneration enzyme

Jennifer M. Vrtis, Andrea K. White, William W. Metcalf, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


The highly thermodynamically favorable oxidation of phosphite to phosphate by phosphite dehydrogenase (PtxD) makes the enzyme useful for cofactor regeneration (see figure). Deuterium exchange in D2O provides labeled phosphite for the preparation of deuterated products.

Original languageEnglish (US)
Pages (from-to)3257-3259
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number17
StatePublished - Sep 2 2002


  • Cofactors
  • Enzyme catalysis
  • Isotopic labeling
  • Nucleotides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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