Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron

Rhanor Gillette; Daniel J. Green

doi:10.1016/0006-8993(83)90868-5

Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron

Research output: Contribution to journal › Article › peer-review

Abstract

Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca²⁺-calmodulin-activated phosphodiesterase is discussed and related to other data.

Original language	English (US)
Pages (from-to)	384-386
Number of pages	3
Journal	Brain Research
Volume	273
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90868-5
State	Published - Aug 29 1983

Keywords

Pleurobranchaea
calmodulin
cyclic AMP
phenothiazine
phosphodiesterase

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)90868-5

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title = "Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron",

abstract = "Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca2+-calmodulin-activated phosphodiesterase is discussed and related to other data.",

keywords = "Pleurobranchaea, calmodulin, cyclic AMP, phenothiazine, phosphodiesterase",

author = "Rhanor Gillette and Green, {Daniel J.}",

note = "Funding Information: This research was supported by NSF Grant BNS 79-18329. Trifluoperazine, chlorpromazine and chlorpromazine sulfoxide were gifts of Smith, Kline and French Laboratories.",

year = "1983",

month = aug,

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doi = "10.1016/0006-8993(83)90868-5",

language = "English (US)",

volume = "273",

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journal = "Brain Research",

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T1 - Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron

AU - Gillette, Rhanor

AU - Green, Daniel J.

N1 - Funding Information: This research was supported by NSF Grant BNS 79-18329. Trifluoperazine, chlorpromazine and chlorpromazine sulfoxide were gifts of Smith, Kline and French Laboratories.

PY - 1983/8/29

Y1 - 1983/8/29

N2 - Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca2+-calmodulin-activated phosphodiesterase is discussed and related to other data.

AB - Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca2+-calmodulin-activated phosphodiesterase is discussed and related to other data.

KW - Pleurobranchaea

KW - calmodulin

KW - cyclic AMP

KW - phenothiazine

KW - phosphodiesterase

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JO - Brain Research

JF - Brain Research

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ER -

Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron

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