Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron

Rhanor Gillette, Daniel J. Green

Research output: Contribution to journalArticle

Abstract

Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca2+-calmodulin-activated phosphodiesterase is discussed and related to other data.

Original languageEnglish (US)
Pages (from-to)384-386
Number of pages3
JournalBrain Research
Volume273
Issue number2
DOIs
StatePublished - Aug 29 1983

Keywords

  • Pleurobranchaea
  • calmodulin
  • cyclic AMP
  • phenothiazine
  • phosphodiesterase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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