Abstract
Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phaseresolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to ∼800 G magnetic fields modulated at 56 and 100 Hz to mechanically actuate embedded iron oxide MNPs (∼20 nm diameter). Sensitivity to 27 μg/g (∼2 nM) MNPs within tissue phantoms is achieved by filtering paramagnetic from diamagnetic vibrations. We demonstrate biological feasibility by imaging topically applied MNPs during their diffusion into an excised rat tumor over a 2 hour time period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11525-11539 |
| Number of pages | 15 |
| Journal | Optics Express |
| Volume | 16 |
| Issue number | 15 |
| State | Published - Jul 21 2008 |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics