Phase Dependent Electrochemical Properties of Polar Self-Assembled Monolayers (SAMs) Modified via the Fusion of Mixed Phospholipid Vesicles

Mariusz Twardowski; Ralph G. Nuzzo

doi:10.1021/la035074d

Phase Dependent Electrochemical Properties of Polar Self-Assembled Monolayers (SAMs) Modified via the Fusion of Mixed Phospholipid Vesicles

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Abstract

The effects of adsorption of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles containing varying quantities of two charged lipids on the subsequent electrochemistry of the underlying self-assembled monolayers are discussed. An enhanced, ionic-charge-specific molecular discrimination of the electrochemical probes was observed. At a composition of 5% 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (DMPG) in DMPC, the permeabilities of the probes were found to be affected significantly relative to that observed with pure DMPC layer. The results suggest that the assembly of secondary adsorbate layers of phospholipids provides an interesting method for modifying the electrochemical properties of thiolate self-assembled monolayers in gold.

Original language	English (US)
Pages (from-to)	175-180
Number of pages	6
Journal	Langmuir
Volume	20
Issue number	1
DOIs	https://doi.org/10.1021/la035074d
State	Published - Jan 6 2004

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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abstract = "The effects of adsorption of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles containing varying quantities of two charged lipids on the subsequent electrochemistry of the underlying self-assembled monolayers are discussed. An enhanced, ionic-charge-specific molecular discrimination of the electrochemical probes was observed. At a composition of 5% 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (DMPG) in DMPC, the permeabilities of the probes were found to be affected significantly relative to that observed with pure DMPC layer. The results suggest that the assembly of secondary adsorbate layers of phospholipids provides an interesting method for modifying the electrochemical properties of thiolate self-assembled monolayers in gold.",

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AU - Nuzzo, Ralph G.

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N2 - The effects of adsorption of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles containing varying quantities of two charged lipids on the subsequent electrochemistry of the underlying self-assembled monolayers are discussed. An enhanced, ionic-charge-specific molecular discrimination of the electrochemical probes was observed. At a composition of 5% 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (DMPG) in DMPC, the permeabilities of the probes were found to be affected significantly relative to that observed with pure DMPC layer. The results suggest that the assembly of secondary adsorbate layers of phospholipids provides an interesting method for modifying the electrochemical properties of thiolate self-assembled monolayers in gold.

AB - The effects of adsorption of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles containing varying quantities of two charged lipids on the subsequent electrochemistry of the underlying self-assembled monolayers are discussed. An enhanced, ionic-charge-specific molecular discrimination of the electrochemical probes was observed. At a composition of 5% 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (DMPG) in DMPC, the permeabilities of the probes were found to be affected significantly relative to that observed with pure DMPC layer. The results suggest that the assembly of secondary adsorbate layers of phospholipids provides an interesting method for modifying the electrochemical properties of thiolate self-assembled monolayers in gold.

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