Phase Dependent Electrochemical Properties of Polar Self-Assembled Monolayers (SAMs) Modified via the Fusion of Mixed Phospholipid Vesicles

Mariusz Twardowski, Ralph G. Nuzzo

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of adsorption of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles containing varying quantities of two charged lipids on the subsequent electrochemistry of the underlying self-assembled monolayers are discussed. An enhanced, ionic-charge-specific molecular discrimination of the electrochemical probes was observed. At a composition of 5% 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (DMPG) in DMPC, the permeabilities of the probes were found to be affected significantly relative to that observed with pure DMPC layer. The results suggest that the assembly of secondary adsorbate layers of phospholipids provides an interesting method for modifying the electrochemical properties of thiolate self-assembled monolayers in gold.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalLangmuir
Volume20
Issue number1
DOIs
StatePublished - Jan 6 2004

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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