Phase correction in low coherence diffraction phase microscopy using the optical transfer function

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, we experimentally determine the transfer function of our recently reported epi-illumination white light diffraction phase microscopy (epi-wDPM) system. The transfer function identifies how the low frequencies below k0NAcon are modified due to the limited spatial coherence and how the high frequencies above k0NAobj are affected due to the limited objective numerical aperture. Using this transfer function, we perform deconvolution to remove the halo and obtain proper quantitative phase measurements without the need for excessive spatial filtering. The wDPM and epi-wDPM systems are now capable of obtaining halo-free images with proper topography at much higher speeds.

Original languageEnglish (US)
Title of host publicationQuantitative Phase Imaging
EditorsYongKeun Park, Gabriel Popescu
PublisherSPIE
ISBN (Electronic)9781628414264
DOIs
StatePublished - Jan 1 2015
Event1st Conference on Quantitative Phase Imaging, QPI 2015 - San Francisco, United States
Duration: Feb 7 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9336
ISSN (Print)1605-7422

Other

Other1st Conference on Quantitative Phase Imaging, QPI 2015
CountryUnited States
CitySan Francisco
Period2/7/152/10/15

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Keywords

  • coherence
  • diffraction phase microscopy
  • halo effect
  • halo removal
  • interferometric microscopy
  • optical inspection
  • optical transfer function
  • quantitative phase imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Edwards, C., Popescu, G., & Goddard, L. L. (2015). Phase correction in low coherence diffraction phase microscopy using the optical transfer function. In Y. Park, & G. Popescu (Eds.), Quantitative Phase Imaging [933610] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9336). SPIE. https://doi.org/10.1117/12.2080318