Pharmacokinetics of pioglitazone in lean and obese cats

M. H. Clark, M. Hoenig, D. C. Ferguson, Levent Dirikolu

Research output: Contribution to journalArticlepeer-review

Abstract

Pioglitazone is a thiazolidinedione insulin sensitizer that has shown efficacy in Type 2 diabetes and nonalcoholic fatty liver disease in humans. It may be useful for treatment of similar conditions in cats. The purpose of this study was to investigate the pharmacokinetics of pioglitazone in lean and obese cats, to provide a foundation for assessment of its effects on insulin sensitivity and lipid metabolism. Pioglitazone was administered intravenously (median 0.2mg/kg) or orally (3mg/kg) to 6 healthy lean (3.96±0.56kg) and 6 obese (6.43±0.48kg) cats, in a two by two Latin Square design with a 4-week washout period. Blood samples were collected over 24h, and pioglitazone concentrations were measured via a validated high-performance liquid chromatography assay. Pharmacokinetic parameters were determined using two-compartmental analysis for IV data and noncompartmental analysis for oral data. After oral administration, mean bioavailability was 55%, t1/2 was 3.5h, Tmax was 3.6h, Cmax was 2131ng/mL, and AUC0-∞ was 15 556 ng/mL·h. There were no statistically significant differences in pharmacokinetic parameters between lean and obese cats following either oral or intravenous administration. Systemic exposure to pioglitazone in cats after a 3mg/kg oral dose approximates that observed in humans with therapeutic doses.

Original languageEnglish (US)
Pages (from-to)428-436
Number of pages9
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume35
Issue number5
DOIs
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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