Pharmacokinetics of ß-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects

Wendy S. White, Maria Stacewicz-Sapuntzakis, John W. Erdman, Phyllis E. Bowen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study investigated effects of ingestion of a combined dose of ß-carotene and canthaxanthin on their individual pharmacokinetics in serum. Methods: During three 5-day study periods, two subjects ingested either a 25 mg dose of ß-carotene, a 25 mg dose of canthaxanthin, or a combined dose of 25 mg each of ß-carotene and canthaxanthin. Pharmacokinetics of the individual and combined doses were compared within subjects. Results: Ingestion of a concurrent ß-carotene dose reduced the peak serum canthaxanthin concentration by 38.8 ± 6.5%, and the 24- and 72-hour areas under the serum canthaxanthin concentrationtime curves by 38.1 ± 6.4 and 34.4 ± 7.4%, respectively. The suggested antagonism between ß-carotene and canthaxanthin was not reciprocal; ß-carotene inhibited the appearance of canthaxanthin in serum but canthaxanthin did not inhibit the appearance of ß-carotene. Conclusion: Our data suggest that ingestion of a combined pharmacologic dose of ß-carotene and canthaxanthin reduces the bioavailability of the canthaxanthin dose.

Original languageEnglish (US)
Pages (from-to)665-671
Number of pages7
JournalJournal of the American College of Nutrition
Volume13
Issue number6
DOIs
StatePublished - Dec 1 1994
Externally publishedYes

Keywords

  • Beta-carotene
  • Canthaxanthin
  • Humans
  • Pharmacokinetics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Pharmacokinetics of ß-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects'. Together they form a unique fingerprint.

Cite this