Pharmacokinetic studies of theophylline in dogs

B. C. McKIERNAN, C. A. NEFF‐DAVIS, G. D. KORITZ, L. E. DAVIS, D. R. PHERIS

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of theophylline were investigated in dogs following intravenous, single oral, and multiple oral doses of aminophylline. Mean half‐life (t1/2) of theophylline following single intravenous administration was 5.7 h and the apparent specific volume of distribution (V'd area) was 0.82 litre/kg. The bioavailability of theophylline was high (91%) following oral administration of aminophylline tablets and the absorption half‐life (t1/2 ab) was 0.4 h. Theophylline plasma concentrations observed following repeated oral administration of aminophylline tablets were somewhat greater than predicted. This suggests that theophylline plasma concentrations should be monitored and the dosage regimen individually adjusted in critically ill animals.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume4
Issue number2
DOIs
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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    McKIERNAN, B. C., NEFF‐DAVIS, C. A., KORITZ, G. D., DAVIS, L. E., & PHERIS, D. R. (1981). Pharmacokinetic studies of theophylline in dogs. Journal of Veterinary Pharmacology and Therapeutics, 4(2), 103-110. https://doi.org/10.1111/j.1365-2885.1981.tb00718.x