The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t 1/2 ) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V' d(area) ) was 0.46 l/kg. The absorption half‐life (t 1/2ab ) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Veterinary Pharmacology and Therapeutics|
|State||Published - Jun 1983|
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