Pharmacokinetic studies of theophylline in cats

B. C. McKIERNAN; G. D. KORITZ; L. E. DAVIS; C. A. NEFF‐DAVIS; D. R. PHERIS

doi:10.1111/j.1365-2885.1983.tb00385.x

Pharmacokinetic studies of theophylline in cats

B. C. McKIERNAN, G. D. KORITZ, L. E. DAVIS, C. A. NEFF‐DAVIS, D. R. PHERIS

Veterinary Clinical Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t_1/2) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V'_d(area)) was 0.46 l/kg. The absorption half‐life (t_1/2ab) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.

Original language	English (US)
Pages (from-to)	99-104
Number of pages	6
Journal	Journal of Veterinary Pharmacology and Therapeutics
Volume	6
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2885.1983.tb00385.x
State	Published - Jun 1983

ASJC Scopus subject areas

Pharmacology
General Veterinary

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10.1111/j.1365-2885.1983.tb00385.x

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title = "Pharmacokinetic studies of theophylline in cats",

abstract = "The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t1/2) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V'd(area)) was 0.46 l/kg. The absorption half‐life (t1/2ab) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.",

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doi = "10.1111/j.1365-2885.1983.tb00385.x",

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AU - McKIERNAN, B. C.

AU - KORITZ, G. D.

AU - DAVIS, L. E.

AU - NEFF‐DAVIS, C. A.

AU - PHERIS, D. R.

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AB - The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t1/2) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V'd(area)) was 0.46 l/kg. The absorption half‐life (t1/2ab) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.

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Pharmacokinetic studies of theophylline in cats

Abstract

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