Pharmacokinetic studies of theophylline in cats

Brendan McKiernan, G. D. KORITZ, L. E. DAVIS, C. A. NEFF‐DAVIS, D. R. PHERIS

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t 1/2 ) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V' d(area) ) was 0.46 l/kg. The absorption half‐life (t 1/2ab ) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume6
Issue number2
DOIs
StatePublished - Jun 1983

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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    McKiernan, B., KORITZ, G. D., DAVIS, L. E., NEFF‐DAVIS, C. A., & PHERIS, D. R. (1983). Pharmacokinetic studies of theophylline in cats. Journal of Veterinary Pharmacology and Therapeutics, 6(2), 99-104. https://doi.org/10.1111/j.1365-2885.1983.tb00385.x