Abstract
The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life (t 1/2 ) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution (V' d(area) ) was 0.46 l/kg. The absorption half‐life (t 1/2ab ) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 99-104 |
| Number of pages | 6 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1983 |
ASJC Scopus subject areas
- Pharmacology
- veterinary(all)