PH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

Pontus Lundberg; Nathaniel A. Lynd; Yuning Zhang; Xianghui Zeng; Daniel V. Krogstad; Tim Paffen; Michael Malkoch; Andreas M. Nyström; Craig J. Hawker

doi:10.1039/c2sm26996a

PH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

Pontus Lundberg, Nathaniel A. Lynd, Yuning Zhang, Xianghui Zeng, Daniel V. Krogstad, Tim Paffen, Michael Malkoch, Andreas M. Nyström, Craig J. Hawker

Research output: Contribution to journal › Article › peer-review

Abstract

Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

Original language	English (US)
Pages (from-to)	82-89
Number of pages	8
Journal	Soft Matter
Volume	9
Issue number	1
DOIs	https://doi.org/10.1039/c2sm26996a
State	Published - Jan 7 2013
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics

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10.1039/c2sm26996a

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abstract = "Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.",

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T1 - PH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

AU - Lundberg, Pontus

AU - Lynd, Nathaniel A.

AU - Zhang, Yuning

AU - Zeng, Xianghui

AU - Krogstad, Daniel V.

AU - Paffen, Tim

AU - Malkoch, Michael

AU - Nyström, Andreas M.

AU - Hawker, Craig J.

PY - 2013/1/7

Y1 - 2013/1/7

N2 - Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

AB - Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

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PH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

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