PH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

Pontus Lundberg, Nathaniel A. Lynd, Yuning Zhang, Xianghui Zeng, Daniel V. Krogstad, Tim Paffen, Michael Malkoch, Andreas M. Nyström, Craig J. Hawker

Research output: Contribution to journalArticlepeer-review


Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalSoft Matter
Issue number1
StatePublished - Jan 7 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics


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