PH-Triggered release from polyamide microcapsules prepared by interfacial polymerization of a simple diester monomer

Hsuan Chin Wang, Joshua M. Grolman, Aoon Rizvi, Grant S. Hisao, Chad M. Rienstra, Steven C. Zimmerman

Research output: Contribution to journalArticle


The majority of current pH-Triggered release systems is designed to respond to either low or high pH. Encapsulants based on polyampholytes are an example of materials that can respond to both acidic and basic pH. However, polyampholyte-based encapsulants generally possess a low loading capacity and have difficulty retaining their small-molecule cargo. The current work utilizes interfacial polymerization between polyamines and a pyromellitic diester diacid chloride to form high capacity "liquid core-shell" polyamide microcapsules that are stable in a dry or nonpolar environment but undergo steady, controlled release at pH 7.4 and accelerated release at pH 5 and pH 10. The rate of release can be tuned by adjusting the amine cross-linker feed ratio, which varies the degree of cross-linking in the polymer shell. The thin-shell microcapsule exhibited suitable barrier properties and tunable dual acid/base-Triggered release, with applications in a wide range of pH environments.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalACS Macro Letters
Issue number3
StatePublished - Jan 1 2017


ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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