pH sensitivity of calmodulin distribution in nervous tissue fractions

Marlene A. Wilson, Rhanor Gillette

Research output: Contribution to journalArticle

Abstract

Alkalinization of nervous system extracts of the mollusk, Pleurobranchaea, from pH 7.0 to 8.0 markedly increases the ratio of soluble to total calmodulin. This effect is independent of pH effects on free Ca2+ concentration and is pronounced at micromolar (near intracellular) levels of Ca2+. These data may relate to recent evidence that Ca2+/calmodulin-activated cyclic nucleotide phosphodiesterase mediates the effects of small changes in intracellular pH (0.1-0.2 units) on the electrical activity of neurons. Calmodulin redistribution could reflect altered availability to stimulate phosphodiesterase activity and supports a a role for calmodulin in mediating effects of intracellular pH fluxes on cellular activity.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalBrain Research
Volume331
Issue number1
DOIs
StatePublished - Apr 1 1985

Keywords

  • Pleurobranchaea
  • calmodulin
  • pH
  • phosphodiesterase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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