pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery

X. Zhu, J. DeGraaf, F. M. Winnik, D. Leckband

Research output: Contribution to journalArticle

Abstract

This study investigated the mucoadhesive property of a hydrophobically modified copolymer N-isopropylacryamide and glycidylacrylamide NIPAM-AT-Gly-(C 18) 2 (NIPAM-Gly). Prior studies demonstrated that the interfacial properties of this copolymer are pH dependent and that the chains form strong hydrogen bonds at pH < 7 via the carboxylic acid side chains of the glycine moieties. Mucin interactions with the copolymer brushes were investigated by surface plasmon resonance and by direct force measurements. Mucin adsorption was determined as a function of pH, ionic strength, and mucin concentration. It adsorbs to the copolymer strongly at pH 5, but the adsorption decreases with increasing pH. The adsorbed amount is also ionic-strength dependent, decreasing with increasing monovalent salt concentrations at all pH values investigated. When compared with similar investigations with poly(ethylene oxide), these results provide insights into both the chemical characteristics and the solution conditions that determine the mucoadhesive properties of polymers.

Original languageEnglish (US)
Pages (from-to)10648-10656
Number of pages9
JournalLangmuir
Volume20
Issue number24
DOIs
StatePublished - Nov 23 2004

Fingerprint

Drug delivery
delivery
copolymers
drugs
Mucins
Copolymers
Ionic strength
Adsorption
Force measurement
Surface plasmon resonance
Brushes
Carboxylic Acids
Polyethylene oxides
Carboxylic acids
Glycine
Amino acids
Hydrogen bonds
Polymers
adsorption
Salts

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery. / Zhu, X.; DeGraaf, J.; Winnik, F. M.; Leckband, D.

In: Langmuir, Vol. 20, No. 24, 23.11.2004, p. 10648-10656.

Research output: Contribution to journalArticle

Zhu, X. ; DeGraaf, J. ; Winnik, F. M. ; Leckband, D. / pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery. In: Langmuir. 2004 ; Vol. 20, No. 24. pp. 10648-10656.
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