Perspectives on the design and control of multiscale systems

R. D. Braatz, R. C. Alkire, E. Seebauer, E. Rusli, R. Gunawan, T. O. Drews, X. Li, Y. He

Research output: Contribution to journalArticlepeer-review


New applications in materials, medicine, and computers are being discovered where the control of events at the molecular and nanoscopic scales is critical to product quality, although the primary manipulation of these events during processing occurs at macroscopic length scales. This motivates the creation of tools for the design and control of multiscale systems that have length scales ranging from the atomistic to the macroscopic. This paper describes a systematic approach that consists of stochastic parameter sensitivity analysis, Bayesian parameter estimation applied to ab initio calculations and experimental data, model-based experimental design, hypothesis mechanism selection, and multistep optimization.

Original languageEnglish (US)
Pages (from-to)193-204
Number of pages12
JournalJournal of Process Control
Issue number3
StatePublished - Mar 2006


  • Complex systems
  • Distributed parameter systems
  • Nonlinear systems
  • Optimal control
  • Stochastic systems
  • System sensitivity
  • Uncertain dynamic systems

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Control and Systems Engineering
  • Industrial and Manufacturing Engineering


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