Peripheral morphine analgesia resistant to tolerance in chronic morphine-treated mice

Hiroshi Ueda, Makoto Inoue

Research output: Contribution to journalArticle

Abstract

Intraplantarly (i.pl.)-injected morphine showed a peripheral analgesia in experiments to assess the blockade of bradykinin (i.pl.)-induced nociceptive flexor response in mice. The peripheral morphine analgesia in mice which developed central analgesic tolerance to chronic morphine (10 mg/kg s.c., 5 days), was equivalent to that in vehicle-treated mice in any doses between 0.1 and 1 nmol (i.pl.). These findings suggest that morphine tolerance in the central analgesia may use unique mechanisms deficient in the peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalNeuroscience Letters
Volume266
Issue number2
DOIs
StatePublished - May 7 1999
Externally publishedYes

Keywords

  • Analgesia
  • Bradykinin
  • Central
  • Morphine
  • Peripheral
  • Tolerance

ASJC Scopus subject areas

  • Neuroscience(all)

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