Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

Adrian J. Green; James L. Graham; Eduardo A. Gonzalez; Michael R. La Frano; Syrago Styliani E. Petropoulou; June Soo Park; John W. Newman; Kimber L. Stanhope; Peter J. Havel; Michele A. La Merrill

doi:10.1016/j.reprotox.2016.07.009

Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

Adrian J. Green, James L. Graham, Eduardo A. Gonzalez, Michael R. La Frano, Syrago Styliani E. Petropoulou, June Soo Park, John W. Newman, Kimber L. Stanhope, Peter J. Havel, Michele A. La Merrill

Research output: Contribution to journal › Article › peer-review

Abstract

Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170 μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

Original language	English (US)
Pages (from-to)	119-129
Number of pages	11
Journal	Reproductive Toxicology
Volume	68
DOIs	https://doi.org/10.1016/j.reprotox.2016.07.009
State	Published - Mar 1 2017
Externally published	Yes

Keywords

Developmental exposure
Diabetes mellitus
Firemaster 550
Hyperphagia
Leptin
Obesity
Triphenyl phosphate

ASJC Scopus subject areas

Toxicology

Online availability

10.1016/j.reprotox.2016.07.009

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Green, A. J., Graham, J. L., Gonzalez, E. A., La Frano, M. R., Petropoulou, S. S. E., Park, J. S., Newman, J. W., Stanhope, K. L., Havel, P. J., & La Merrill, M. A. (2017). Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reproductive Toxicology, 68, 119-129. https://doi.org/10.1016/j.reprotox.2016.07.009

Green, AJ, Graham, JL, Gonzalez, EA, La Frano, MR, Petropoulou, SSE, Park, JS, Newman, JW, Stanhope, KL, Havel, PJ & La Merrill, MA 2017, 'Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats', Reproductive Toxicology, vol. 68, pp. 119-129. https://doi.org/10.1016/j.reprotox.2016.07.009

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title = "Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats",

abstract = "Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170 μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.",

keywords = "Developmental exposure, Diabetes mellitus, Firemaster 550, Hyperphagia, Leptin, Obesity, Triphenyl phosphate",

author = "Green, {Adrian J.} and Graham, {James L.} and Gonzalez, {Eduardo A.} and {La Frano}, {Michael R.} and Petropoulou, {Syrago Styliani E.} and Park, {June Soo} and Newman, {John W.} and Stanhope, {Kimber L.} and Havel, {Peter J.} and {La Merrill}, {Michele A.}",

note = "Funding Information: The NIH (ES023513, DK095980, HL107256, HL121324, U24DK092993, U24DK097154), Office of Environmental Health Hazard Assessment (agreement number 13-E0014-1), the USDA (National Institute of Food and Agriculture, Hatch project 1002182 and Intramural Project 2032-51530-022-00D), and a multi-campus grant from the University of California Office of the President. The USDA is an equal opportunity provider and employer. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.reprotox.2016.07.009",

language = "English (US)",

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T1 - Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

AU - Green, Adrian J.

AU - Graham, James L.

AU - Gonzalez, Eduardo A.

AU - La Frano, Michael R.

AU - Petropoulou, Syrago Styliani E.

AU - Park, June Soo

AU - Newman, John W.

AU - Stanhope, Kimber L.

AU - Havel, Peter J.

AU - La Merrill, Michele A.

N1 - Funding Information: The NIH (ES023513, DK095980, HL107256, HL121324, U24DK092993, U24DK097154), Office of Environmental Health Hazard Assessment (agreement number 13-E0014-1), the USDA (National Institute of Food and Agriculture, Hatch project 1002182 and Intramural Project 2032-51530-022-00D), and a multi-campus grant from the University of California Office of the President. The USDA is an equal opportunity provider and employer. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170 μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

AB - Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170 μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

KW - Developmental exposure

KW - Diabetes mellitus

KW - Firemaster 550

KW - Hyperphagia

KW - Leptin

KW - Obesity

KW - Triphenyl phosphate

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Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

Abstract

Keywords

ASJC Scopus subject areas

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