Peptides and regulation of calcium channels

Zuojun Lin (Inventor), Philip M Best (Inventor), Thomas Garcia (Inventor), Ren-Shiang Chen (Inventor)

Research output: Patent

Abstract

Calcium channels can be regulated by natural gamma proteins. Herein we disclose embodiments of compositions and methods, particularly involving short peptides which are capable of regulating calcium channel function. Certain short peptides which can inhibit calcium current have structural features from the first transmembrane domain of gamma6 such as a GxxxA motif and adjoining aliphatic residues. In embodiments the peptide compositions and methods are capable of selective efficacy for low voltage-activated calcium channels, such as LVA channel Cav3.1, versus high voltage-activated channels.
Original languageEnglish (US)
U.S. patent number8299211
Filing date4/24/09
StatePublished - Oct 30 2012

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