Peptides and calcium regulation in mammalian cells

Zuojun Lin (Inventor), Jared Hansen (Inventor), Philip M Best (Inventor), Poju Chu (Inventor), Janice K Jones (Inventor), Karen Weis (Inventor)

Research output: Patent

Abstract

Calcium channels in a variety of tissues may contain different subunits, including several different γ (gamma) subunits. We report studies regarding structural features of certain gamma subunits, for example the N-terminal first transmembrane domain (TM1) of the subunit γ6. We disclose that certain structural motifs, for example a GxxxG-like structural motif as described herein, can mediate subunit function for calcium channels. A particular peptide motif that has been identified as significant for the ability to mediate a decrease in calcium current is GxxxA. Compositions and methods are disclosed which are useful in modifying calcium regulation in mammalian cells. In various embodiments, calcium current is modified.
Original languageEnglish (US)
U.S. patent number8022177
Filing date9/29/06
StatePublished - Sep 20 2011

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