TY - JOUR
T1 - Peptide dendrimers from natural amino acids
AU - Kim, Yoonkyung
AU - Zeng, Fanwen
AU - Zimmerman, Steven C.
PY - 1999
Y1 - 1999
N2 - The high-yielding cyanoethylation-hydrogenation strategy was used to prepare simple AB2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.
AB - The high-yielding cyanoethylation-hydrogenation strategy was used to prepare simple AB2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.
KW - Amino acids
KW - Dendrimers
KW - Peptides
KW - Solid-phase synthesis
UR - http://www.scopus.com/inward/record.url?scp=85088546095&partnerID=8YFLogxK
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U2 - 10.1002/(sici)1521-3765(19990702)5:7<2133::aid-chem2133>3.3.co;2-a
DO - 10.1002/(sici)1521-3765(19990702)5:7<2133::aid-chem2133>3.3.co;2-a
M3 - Article
AN - SCOPUS:85088546095
SN - 0947-6539
VL - 5
SP - 2133
EP - 2138
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 7
ER -