The high-yielding cyanoethylation-hydrogenation strategy was used to prepare simple AB2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.
|Original language||English (US)|
|Number of pages||6|
|Journal||Chemistry - A European Journal|
|State||Published - 1999|
- Amino acids
- Solid-phase synthesis
ASJC Scopus subject areas