Peptide dendrimers from natural amino acids

Yoonkyung Kim, Fanwen Zeng, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review

Abstract

The high-yielding cyanoethylation-hydrogenation strategy was used to prepare simple AB2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.

Original languageEnglish (US)
Pages (from-to)2133-2138
Number of pages6
JournalChemistry - A European Journal
Volume5
Issue number7
DOIs
StatePublished - 1999

Keywords

  • Amino acids
  • Dendrimers
  • Peptides
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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