Peptide arrays identify isoform-selective substrates for profiling endogenous lysine deacetylase activity

Keyphrases

• Deacetylase Activity 100%
• Isoform Selectivity 100%
• Selective Substrate 100%
• Peptide Array 100%
• Lysine Deacetylase 100%
• Self-assembled Monolayer 66%
• Label-free 33%
• Cell Culture 33%
• Fluorescence Assay 33%
• Alkanethiolates 33%
• HeLa 33%
• HeLa Cells 33%
• Enzyme Activity 33%
• Mass Spectrometry Methods 33%
• Substrate Specificity 33%
• Matrix-assisted Laser Desorption Ionization-time of Flight Mass Spectrometry (MALDI-TOF MS) 33%
• Biological Processes 33%
• Smooth muscle Cells 33%
• Acetylation 33%
• Enzyme Family 33%
• Peptide Substrate 33%
• Deacetylase 33%
• Terminal Residue 33%
• Nuclear Extract 33%
• Acetylated Lysine 33%
• Hexapeptide 33%
• Activity Profile 33%
• Sirtuin 1 (SIRT1) 33%
• Cell Cycle Regulation 33%
• Jurkat 33%
• SAMDI 33%
• H4 Histones 33%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Lysine 100%
• Enzyme 66%
• Matrix-Assisted Laser Desorption/Ionization 33%
• Mass Spectrometry 33%
• Cell Culture 33%
• Enzyme Specificity 33%
• Enzyme Activity 33%
• C-Terminus 33%
• Biological Phenomena and Functions Concerning the Entire Organism 33%
• Time-of-Flight Mass Spectrometry 33%
• Extract 33%
• Cell Cycle 33%
• Acetylation 33%
• Histone H4 33%
• Cell Cycle Regulation 33%
• Sirtuin 1 33%