PEG-polypeptide dual brush block copolymers: Synthesis and application in nanoparticle surface PEGylation

Yanfeng Zhang, Qian Yin, Hua Lu, Hongwei Xia, Yao Lin, Jianjun Cheng

Research output: Contribution to journalArticle


Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N-(2-((trimethylsilyl)amino)ethyl)-5- norbornene-endo-2,3-dicarboximide (M1), followed by ring-opening polymerization of amino acid N-carboxyanhydrides. Polylactide nanoparticles coated with these amphiphilic dual brush block copolymers showed significantly improved stability in PBS solution compared to those coated with amphiphilic linear block copolymers such as PEG-polylactide and PEG-polypeptides.

Original languageEnglish (US)
Pages (from-to)809-813
Number of pages5
JournalACS Macro Letters
Issue number9
StatePublished - Sep 24 2013


ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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