An experimental program to compare pavement responses caused by newgeneration Wide-Base Tires (WBT) with the conventional Dual- Tire Assembly (DTA) is presented. Four pavement sections were built, tested, and instrumented at two test sites: Two sections at Florida DOT facility and two sections at UC-Davis. H- Type strain gauges at the bottom of the Asphalt Concrete (AC) and pressure cells on top of the base and the subbase were installed at each test site. Instrumentation also included surface foil gauges in Florida and a multi-depth deflectometer at UC-Davis. All sections were subjected to the same test loading: five tire loads (26.2, 36.2, 44.4, 62.1, and 79.9 kN) and four tire inflation pressures (552, 690, 758, and 862 kPa) at three temperatures using the two types of tires considered. In addition, two cases of differential tire inflation pressures were included for DTA (552/758 and 414/758 kPa). Pavement responses to a tire loading of 44 kN and tire inflation pressure of 758 kPa for both tires are presented. Data analysis and impact of tire type on pavement responses is discussed. This paper is part of the pooled-fund project TPF-5(197), The Impact of Wide-Base Tires on Pavement Damage: A National Study.