Patterns of Brain Activity Associated with Variation in Voluntary Wheel-Running Behavior

Justin S. Rhodes, Theodore Garland, Stephen C. Gammie

Research output: Contribution to journalArticlepeer-review

Abstract

Rodents spontaneously run on wheels, but what underlies variation within and between species is unknown. This study used Fos immunoreactivity to compare brain activity in mice selectively bred for high wheel running (S) versus control (C) mice. Mice ran for 6 days, but on Day 7, half the mice were prevented from running. A strong positive correlation was found between running distance and Fos in the dentate gyrus of C runners that was lost in S runners. In mice prevented from running, Fos was higher in S than in C in the lateral hypothalamus, medial frontal cortex, and striatum. Results implicate specific brain regions in motivation to run and others in control of the intensity of the locomotor behavior itself.

Original languageEnglish (US)
Pages (from-to)1243-1256
Number of pages14
JournalBehavioral Neuroscience
Volume117
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience

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