Pattern formation in Dictyostelium discoideum: An analysis of mutants altered in cell proportioning

James H. Morrissey; Paul A. Farnsworth; William F. Loomis

doi:10.1016/S0012-1606(81)80002-4

Pattern formation in Dictyostelium discoideum: An analysis of mutants altered in cell proportioning

James H. Morrissey, Paul A. Farnsworth, William F. Loomis

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies of Dictyostelium discoideum have demonstrated that the cells in the anterior fifth of the migrating slug differ biochemically and ultrastructurally from the posterior cells. This pattern of differentiation has been correlated with the difference in prospective fate of the two clel types, which has led to the conclusion that preparations essential for spore and stalk differentiation begin during the slug stage. We report the analysis of mutants in which the proportions of spore and stalk cells is drastically altered and yet in which the pattern of several differentiations in slugs is essentially wild type. Models relating to pattern formation and morphogenesis in D. discoideum are discussed in light of these results.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Developmental Biology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/S0012-1606(81)80002-4
State	Published - Apr 15 1981
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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abstract = "Previous studies of Dictyostelium discoideum have demonstrated that the cells in the anterior fifth of the migrating slug differ biochemically and ultrastructurally from the posterior cells. This pattern of differentiation has been correlated with the difference in prospective fate of the two clel types, which has led to the conclusion that preparations essential for spore and stalk differentiation begin during the slug stage. We report the analysis of mutants in which the proportions of spore and stalk cells is drastically altered and yet in which the pattern of several differentiations in slugs is essentially wild type. Models relating to pattern formation and morphogenesis in D. discoideum are discussed in light of these results.",

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AU - Loomis, William F.

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AB - Previous studies of Dictyostelium discoideum have demonstrated that the cells in the anterior fifth of the migrating slug differ biochemically and ultrastructurally from the posterior cells. This pattern of differentiation has been correlated with the difference in prospective fate of the two clel types, which has led to the conclusion that preparations essential for spore and stalk differentiation begin during the slug stage. We report the analysis of mutants in which the proportions of spore and stalk cells is drastically altered and yet in which the pattern of several differentiations in slugs is essentially wild type. Models relating to pattern formation and morphogenesis in D. discoideum are discussed in light of these results.

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Pattern formation in Dictyostelium discoideum: An analysis of mutants altered in cell proportioning

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