Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel

Jee Wei Emily Chen, Jan Lumibao, H Rex Gaskins, Brendan A Harley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Glioblastoma (GBM) is the most common and deadly form of brain cancer. Despite the current standard-of-care, patient prognosis is still poor (median survival ~15months; 5+ year survival <10%). Tumor-associated microglia and macrophages (TAMs) in the GBM tumor microenvironment (TME) are believed to be powerful regulators of GBM invasion and therapeutic outcomes. This work focuses on investigating crosstalk between patient-derived GBM biospecimens and TAMs within a gelatin hydrogel platform to uncover the role of GBM-microglial interactions on GBM invasion, microglia activation, and therapeutic resistance.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Hydrogel
Microglia
Gelatin
Glioblastoma
Hydrogels
Tumors
Macrophages
Crosstalk
Brain
Chemical activation
Tumor Microenvironment
Survival
Standard of Care
Brain Neoplasms
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Chen, J. W. E., Lumibao, J., Gaskins, H. R., & Harley, B. A. (2019). Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel. / Chen, Jee Wei Emily; Lumibao, Jan; Gaskins, H Rex; Harley, Brendan A.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, JWE, Lumibao, J, Gaskins, HR & Harley, BA 2019, Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Chen JWE, Lumibao J, Gaskins HR, Harley BA. Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Chen, Jee Wei Emily ; Lumibao, Jan ; Gaskins, H Rex ; Harley, Brendan A. / Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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