Patient-adapted reconstruction and acquisition dynamic imaging method (PARADIGM) for MRI

Nitin Aggarwal, Yoram Bresler

Research output: Contribution to journalArticlepeer-review


Dynamic magnetic resonance imaging (MRI) is a challenging problem because the MR data acquisition is often not fast enough to meet the combined spatial and temporal Nyquist sampling rate requirements. Current approaches to this problem include hardware-based acceleration of the acquisition, and model-based image reconstruction techniques. In this paper we propose an alternative approach, called PARADIGM, which adapts both the acquisition and reconstruction to the spatio-temporal characteristics of the imaged object. The approach is based on time-sequential sampling theory, addressing the problem of acquiring a spatio-temporal signal under the constraint that only a limited amount of data can be acquired at a time instant. PARADIGM identifies a model class for the particular imaged object using a scout MR scan or auxiliary data. This object-adapted model is then used to optimize MR data acquisition, such that the imaging constraints are met, acquisition speed requirements are minimized, essentially perfect reconstruction of any object in the model class is guaranteed, and the inverse problem of reconstructing the dynamic object has a condition number of one. We describe spatio-temporal object models for various dynamic imaging applications including cardiac imaging. We present the theory underlying PARADIGM and analyze its performance theoretically and numerically. We also propose a practical MR imaging scheme for 2D dynamic cardiac imaging based on the theory. For this application, PARADIGM is predicted to provide a 10-25 × acceleration compared to the optimal non-adaptive scheme. Finally we present generalized optimality criteria and extend the scheme to dynamic imaging with three spatial dimensions.

Original languageEnglish (US)
Article number045015
JournalInverse Problems
Issue number4
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Signal Processing
  • Mathematical Physics
  • Computer Science Applications
  • Applied Mathematics

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