Pathways of Oxidative Damage

Research output: Contribution to journalReview articlepeer-review

Abstract

The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously nonspecific, transferring electrons to any good acceptor with which they make electronic contact. This poses a problem for aerobic organisms, since molecular oxygen is small enough to penetrate all but the most shielded active sites of redox enzymes. Adventitious electron transfers to oxygen create superoxide and hydrogen peroxide, which are partially reduced species that can oxidize biomolecules with which oxygen itself reacts poorly. This review attempts to present our still-incomplete understanding of how reactive oxygen species are formed inside cells and the mechanisms by which they damage specific target molecules. The vulnerability of cells to oxidation lies at the root of obligate anaerobiosis, spontaneous mutagenesis, and the use of oxidative stress as a biological weapon.

Original languageEnglish (US)
Pages (from-to)395-418
Number of pages24
JournalAnnual review of microbiology
Volume57
DOIs
StatePublished - 2003

Keywords

  • Catalase
  • Hydrogen peroxide
  • Hydroxyl radical
  • Superoxide
  • Superoxide dismutase

ASJC Scopus subject areas

  • Microbiology

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