Pathway design, engineering, and optimization

Eva Garcia-Ruiz, Mohammad HamediRad, Huimin Zhao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The microbial metabolic versatility found in nature has inspired scientists to create microorganisms capable of producing value-added compounds. Many endeavors have been made to transfer and/or combine pathways, existing or even engineered enzymes with new function to tractable microorganisms to generate new metabolic routes for drug, biofuel, and specialty chemical production. However, the success of these pathways can be impeded by different complications from an inherent failure of the pathway to cell perturbations. Pursuing ways to overcome these shortcomings, a wide variety of strategies have been developed. This chapter will review the computational algorithms and experimental tools used to design efficient metabolic routes, and construct and optimize biochemical pathways to produce chemicals of high interest.

Original languageEnglish (US)
Title of host publicationAdvances in Biochemical Engineering/Biotechnology
PublisherSpringer Science and Business Media Deutschland GmbH
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume162
ISSN (Print)0724-6145

Fingerprint

Biofuels
Microorganisms
Enzymes
Pharmaceutical Preparations

Keywords

  • Cell factories
  • DNA assembly
  • Metabolic engineering
  • Pathway construction
  • Pathway design
  • Pathway optimization
  • Synthetic biology

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Garcia-Ruiz, E., HamediRad, M., & Zhao, H. (2018). Pathway design, engineering, and optimization. In Advances in Biochemical Engineering/Biotechnology (Advances in Biochemical Engineering/Biotechnology; Vol. 162). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/10_2016_12

Pathway design, engineering, and optimization. / Garcia-Ruiz, Eva; HamediRad, Mohammad; Zhao, Huimin.

Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, 2018. (Advances in Biochemical Engineering/Biotechnology; Vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

Garcia-Ruiz, E, HamediRad, M & Zhao, H 2018, Pathway design, engineering, and optimization. in Advances in Biochemical Engineering/Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol. 162, Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/10_2016_12
Garcia-Ruiz E, HamediRad M, Zhao H. Pathway design, engineering, and optimization. In Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH. 2018. (Advances in Biochemical Engineering/Biotechnology). https://doi.org/10.1007/10_2016_12
Garcia-Ruiz, Eva ; HamediRad, Mohammad ; Zhao, Huimin. / Pathway design, engineering, and optimization. Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, 2018. (Advances in Biochemical Engineering/Biotechnology).
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