PathSTORM: a road to early cancer detection

Kris Troy; Yang Liu; Sarah J. Hainer

doi:10.1080/23723556.2020.1776086

PathSTORM: a road to early cancer detection

Kris Troy
, Yang Liu
, Sarah J. Hainer

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

Original language	English (US)
Article number	1776086
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	5
Early online date	Jun 21 2020
DOIs	https://doi.org/10.1080/23723556.2020.1776086
State	Published - Sep 2 2020
Externally published	Yes

Keywords

chromatin
CUT&RUN
diagnostics
oncogenesis
PathSTORM

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Online availability

10.1080/23723556.2020.1776086

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title = "PathSTORM: a road to early cancer detection",

abstract = "Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.",

keywords = "chromatin, CUT\&RUN, diagnostics, oncogenesis, PathSTORM",

author = "Kris Troy and Yang Liu and Hainer, \{Sarah J.\}",

note = "PathSTORM chromatin CUT\&RUN oncogenesis diagnostics National Institute of Health R33CA225494 R01CA185363 to Y.L. and R35GM133732 to S.J.H This manuscript was supported by the National Institute of Health Grant numbers R33CA225494, R01CA185363 to Y.L. and R35GM133732 to S.J.H.",

year = "2020",

month = sep,

day = "2",

doi = "10.1080/23723556.2020.1776086",

language = "English (US)",

volume = "7",

journal = "Molecular and Cellular Oncology",

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T2 - a road to early cancer detection

AU - Troy, Kris

AU - Liu, Yang

AU - Hainer, Sarah J.

N1 - PathSTORM chromatin CUT&RUN oncogenesis diagnostics National Institute of Health R33CA225494 R01CA185363 to Y.L. and R35GM133732 to S.J.H This manuscript was supported by the National Institute of Health Grant numbers R33CA225494, R01CA185363 to Y.L. and R35GM133732 to S.J.H.

PY - 2020/9/2

Y1 - 2020/9/2

N2 - Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

AB - Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

KW - chromatin

KW - CUT&RUN

KW - diagnostics

KW - oncogenesis

KW - PathSTORM

UR - https://www.scopus.com/pages/publications/85087374512

UR - https://www.scopus.com/pages/publications/85087374512#tab=citedBy

U2 - 10.1080/23723556.2020.1776086

DO - 10.1080/23723556.2020.1776086

M3 - Comment/debate

AN - SCOPUS:85087374512

SN - 2372-3556

VL - 7

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 5

M1 - 1776086

ER -

PathSTORM: a road to early cancer detection

Abstract

Keywords

ASJC Scopus subject areas

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