PathSTORM: a road to early cancer detection

Kris Troy; Yang Liu; Sarah J. Hainer

doi:10.1080/23723556.2020.1776086

PathSTORM: a road to early cancer detection

Kris Troy, Yang Liu, Sarah J. Hainer

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

Original language	English (US)
Article number	1776086
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	5
Early online date	Jun 21 2020
DOIs	https://doi.org/10.1080/23723556.2020.1776086
State	Published - Sep 2 2020
Externally published	Yes

Keywords

chromatin
CUT&RUN
diagnostics
oncogenesis
PathSTORM

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Online availability

10.1080/23723556.2020.1776086

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title = "PathSTORM: a road to early cancer detection",

abstract = "Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.",

keywords = "chromatin, CUT&RUN, diagnostics, oncogenesis, PathSTORM",

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year = "2020",

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AU - Liu, Yang

AU - Hainer, Sarah J.

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AB - Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

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KW - diagnostics

KW - oncogenesis

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PathSTORM: a road to early cancer detection

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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