PathSTORM: a road to early cancer detection

Kris Troy, Yang Liu, Sarah J. Hainer

Research output: Contribution to journalComment/debatepeer-review

Abstract

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

Original languageEnglish (US)
Article number1776086
JournalMolecular and Cellular Oncology
Volume7
Issue number5
DOIs
StatePublished - Sep 2 2020
Externally publishedYes

Keywords

  • chromatin
  • CUT&RUN
  • diagnostics
  • oncogenesis
  • PathSTORM

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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