Pathophysiology and pharmacology of GABAA receptors

H. Möhler, J. M. Fritschy, K. Vogt, F. Crestani, U. Rudolph

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective GABAA receptor subtypes, therefore, provide new opportunities not only for understanding GABA-dependent pathophysiologies but also for targeting of selective neuronal circuits by drugs. The pharmacological relevance of GABAA receptor subtypes is increasingly being recognized. A new central nervous system pharmacology is on the horizon. The development of anxiolytic drugs devoid of sedation and of agents that enhance hippocampus-dependent learning and memory has become a novel and highly selective therapeutic opportunity.

Original languageEnglish (US)
Title of host publicationAnxiety and Anxiolytic Drugs
PublisherSpringer
Pages225-247
Number of pages23
ISBN (Print)9783540225683
DOIs
StatePublished - 2005
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume169
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Anxiolytics
  • Epilepsy
  • Hypnotics
  • Memory
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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