Pathophysiology and pharmacology of GABA(A) receptors.

H. Möhler, J. M. Fritschy, K. Vogt, F. Crestani, U. Rudolph

Research output: Contribution to journalArticlepeer-review


By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective GABA(A) receptor subtypes, therefore, provide new opportunities not only for understanding GABA-dependent pathophysiologies but also for targeting of selective neuronal circuits by drugs. The pharmacological relevance of GABA(A) receptor subtypes is increasingly being recognized. A new central nervous system pharmacology is on the horizon. The development of anxiolytic drugs devoid of sedation and of agents that enhance hippocampus-dependent learning and memory has become a novel and highly selective therapeutic opportunity.

Original languageEnglish (US)
Pages (from-to)225-247
Number of pages23
JournalHandbook of Experimental Pharmacology
Issue number169
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)


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