Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

Agnieszka Owczarczyk-Saczonek, Dorota Purzycka-Bohdan, Bogusław Nedoszytko, Adam Reich, Aneta Szczerkowska-Dobosz, Joanna Bartosiñska, Aleksandra Batycka-Baran, Rafał Czajkowski, Iwona T Dobrucki, Lawrence W Dobrucki, Magdalena Górecka-Sokołowska, Anna Janaszak-Jasiecka, Leszek Kalinowski, Dorota Krasowska, Adrianna Radulska, Edyta Reszka, Dominik Samotij, Andrzej Słominski, Radomir Słominski, Marta Sobalska-KwapisMarta Stawczyk-Macieja, Dominik Strapagiel, Justyna Szczêch, Michał Żmijewski, Roman J Nowicki

Research output: Contribution to journalReview articlepeer-review


Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.

Original languageEnglish (US)
Pages (from-to)452-467
Number of pages16
JournalPostepy Dermatologii I Alergologii
Issue number4
StatePublished - Aug 2020


  • Inflammation
  • Metabolic syndrome
  • Metabolomics
  • Proteomic nutrigenomics
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy


Dive into the research topics of 'Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis'. Together they form a unique fingerprint.

Cite this