TY - JOUR
T1 - Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
AU - Owczarczyk-Saczonek, Agnieszka
AU - Purzycka-Bohdan, Dorota
AU - Nedoszytko, Bogusław
AU - Reich, Adam
AU - Szczerkowska-Dobosz, Aneta
AU - Bartosiñska, Joanna
AU - Batycka-Baran, Aleksandra
AU - Czajkowski, Rafał
AU - Dobrucki, Iwona T
AU - Dobrucki, Lawrence W
AU - Górecka-Sokołowska, Magdalena
AU - Janaszak-Jasiecka, Anna
AU - Kalinowski, Leszek
AU - Krasowska, Dorota
AU - Radulska, Adrianna
AU - Reszka, Edyta
AU - Samotij, Dominik
AU - Słominski, Andrzej
AU - Słominski, Radomir
AU - Sobalska-Kwapis, Marta
AU - Stawczyk-Macieja, Marta
AU - Strapagiel, Dominik
AU - Szczêch, Justyna
AU - Żmijewski, Michał
AU - Nowicki, Roman J
N1 - Funding Information:
This work is supported by grant of the Polish Ministry of Science and Higher Education no. 02-0066/07/253.
PY - 2020/8
Y1 - 2020/8
N2 - Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.
AB - Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.
KW - Inflammation
KW - Metabolic syndrome
KW - Metabolomics
KW - Proteomic nutrigenomics
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=85090485823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090485823&partnerID=8YFLogxK
U2 - 10.5114/ada.2020.98284
DO - 10.5114/ada.2020.98284
M3 - Review article
C2 - 32994764
SN - 1642-395X
VL - 37
SP - 452
EP - 467
JO - Postepy Dermatologii I Alergologii
JF - Postepy Dermatologii I Alergologii
IS - 4
ER -