Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.
Original language | English (US) |
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Pages (from-to) | 256-263 |
Number of pages | 8 |
Journal | Current Opinion in Virology |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Virology