Pathogenesis of porcine reproductive and respiratory syndrome virus

Ranjni J. Chand, Benjamin R. Trible, Raymond R.R. Rowland

Research output: Contribution to journalReview articlepeer-review


Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalCurrent Opinion in Virology
Issue number3
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • Virology


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