Pathogenesis of porcine reproductive and respiratory syndrome virus

Ranjni J. Chand; Benjamin R. Trible; Raymond R.R. Rowland

doi:10.1016/j.coviro.2012.02.002

Pathogenesis of porcine reproductive and respiratory syndrome virus

Ranjni J. Chand, Benjamin R. Trible, Raymond R.R. Rowland

Research output: Contribution to journal › Review article

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.

Original language	English (US)
Pages (from-to)	256-263
Number of pages	8
Journal	Current Opinion in Virology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.coviro.2012.02.002
State	Published - Jun 1 2012
Externally published	Yes

ASJC Scopus subject areas

Virology

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Chand, R. J., Trible, B. R., & Rowland, R. R. R. (2012). Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology, 2(3), 256-263. https://doi.org/10.1016/j.coviro.2012.02.002

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