Abstract
The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric Gq-, Gi- and G 12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.
| Original language | English (US) |
|---|---|
| Title of host publication | Pasteurella multocida |
| Subtitle of host publication | Molecular Biology, Toxins and Infection |
| Editors | Klaus Aktories, Joachim Orth, Ben Adler |
| Pages | 93-111 |
| Number of pages | 19 |
| DOIs | |
| State | Published - Nov 8 2012 |
Publication series
| Name | Current Topics in Microbiology and Immunology |
|---|---|
| Volume | 361 |
| ISSN (Print) | 0070-217X |
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ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology
- Immunology
- Microbiology (medical)
Cite this
Pasteurella multocida toxin interaction with host cells : Entry and cellular effects. / Wilson, Brenda A.; Ho, Mengfei.
Pasteurella multocida: Molecular Biology, Toxins and Infection. ed. / Klaus Aktories; Joachim Orth; Ben Adler. 2012. p. 93-111 (Current Topics in Microbiology and Immunology; Vol. 361).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Pasteurella multocida toxin interaction with host cells
T2 - Entry and cellular effects
AU - Wilson, Brenda A.
AU - Ho, Mengfei
PY - 2012/11/8
Y1 - 2012/11/8
N2 - The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric Gq-, Gi- and G 12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.
AB - The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric Gq-, Gi- and G 12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.
UR - http://www.scopus.com/inward/record.url?scp=84868305001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868305001&partnerID=8YFLogxK
U2 - 10.1007/82-2012-219
DO - 10.1007/82-2012-219
M3 - Chapter
C2 - 22552700
AN - SCOPUS:84868305001
SN - 9783642310164
T3 - Current Topics in Microbiology and Immunology
SP - 93
EP - 111
BT - Pasteurella multocida
A2 - Aktories, Klaus
A2 - Orth, Joachim
A2 - Adler, Ben
ER -