Pasteurella multocida toxin interaction with host cells: Entry and cellular effects

Brenda A. Wilson, Mengfei Ho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric Gq-, Gi- and G 12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.

Original languageEnglish (US)
Title of host publicationPasteurella multocida
Subtitle of host publicationMolecular Biology, Toxins and Infection
EditorsKlaus Aktories, Joachim Orth, Ben Adler
Pages93-111
Number of pages19
DOIs
StatePublished - Nov 8 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume361
ISSN (Print)0070-217X

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Wilson, B. A., & Ho, M. (2012). Pasteurella multocida toxin interaction with host cells: Entry and cellular effects. In K. Aktories, J. Orth, & B. Adler (Eds.), Pasteurella multocida: Molecular Biology, Toxins and Infection (pp. 93-111). (Current Topics in Microbiology and Immunology; Vol. 361). https://doi.org/10.1007/82-2012-219