Pasteurella multocida toxin interaction with host cells: Entry and cellular effects

Brenda A. Wilson; Mengfei Ho

doi:10.1007/82-2012-219

Pasteurella multocida toxin interaction with host cells: Entry and cellular effects

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G_q-, G_i- and G _12/13-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.

Original language	English (US)
Title of host publication	Pasteurella multocida
Subtitle of host publication	Molecular Biology, Toxins and Infection
Editors	Klaus Aktories, Joachim Orth, Ben Adler
Pages	93-111
Number of pages	19
DOIs	https://doi.org/10.1007/82-2012-219
State	Published - Nov 8 2012

Publication series

Name	Current Topics in Microbiology and Immunology
Volume	361
ISSN (Print)	0070-217X

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ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

Cite this

Wilson, B. A., & Ho, M. (2012). Pasteurella multocida toxin interaction with host cells: Entry and cellular effects. In K. Aktories, J. Orth, & B. Adler (Eds.), Pasteurella multocida: Molecular Biology, Toxins and Infection (pp. 93-111). (Current Topics in Microbiology and Immunology; Vol. 361). https://doi.org/10.1007/82-2012-219

Pasteurella multocida toxin interaction with host cells : Entry and cellular effects. / Wilson, Brenda A.; Ho, Mengfei.

Pasteurella multocida: Molecular Biology, Toxins and Infection. ed. / Klaus Aktories; Joachim Orth; Ben Adler. 2012. p. 93-111 (Current Topics in Microbiology and Immunology; Vol. 361).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Access to Document

10.1007/82-2012-219