Abstract

Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.

Original languageEnglish (US)
Pages (from-to)93-109
Number of pages17
JournalReviews of Physiology, Biochemistry and Pharmacology
Volume152
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Physiology (medical)

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