Pasteurella multocida toxin as a tool for studying Gq signal transduction

B. A. Wilson; M. Ho

doi:10.1007/s10254-004-0032-6

Pasteurella multocida toxin as a tool for studying G_q signal transduction

Research output: Contribution to journal › Review article › peer-review

Abstract

Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gα_q subunit. This review summarizes what is currently known about the molecular action of PMT on G_q and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.

Original language	English (US)
Pages (from-to)	93-109
Number of pages	17
Journal	Reviews of Physiology, Biochemistry and Pharmacology
Volume	152
DOIs	https://doi.org/10.1007/s10254-004-0032-6
State	Published - Dec 2004

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Physiology (medical)

Online availability

10.1007/s10254-004-0032-6

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Cite this

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abstract = "Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.",

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