TY - JOUR
T1 - Pasteurella multocida toxin as a tool for studying Gq signal transduction
AU - Wilson, B. A.
AU - Ho, M.
PY - 2004/12
Y1 - 2004/12
N2 - Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.
AB - Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.
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UR - http://www.scopus.com/inward/citedby.url?scp=21644478698&partnerID=8YFLogxK
U2 - 10.1007/s10254-004-0032-6
DO - 10.1007/s10254-004-0032-6
M3 - Review article
C2 - 15455260
AN - SCOPUS:21644478698
SN - 0303-4240
VL - 152
SP - 93
EP - 109
JO - Reviews of Physiology, Biochemistry and Pharmacology
JF - Reviews of Physiology, Biochemistry and Pharmacology
ER -