Pasteurella multocida: Genotypes and genomics

Zhong Peng, Xiangru Wang, Rui Zhou, Huanchun Chen, Brenda Anne Wilson, Bin Wu

Research output: Contribution to journalReview article

Abstract

Pasteurella multocida is a highly versatile pathogen capable of causing infections in a wide range of domestic and wild animals as well as in humans and nonhuman primates. Despite over 135 years of research, the molecular basis for the myriad manifestations of P. multocida pathogenesis and the determinants of P. multocida phylogeny remain poorly defined. The current availability of multiple P. multocida genome sequences now makes it possible to delve into the underlying genetic mechanisms of P. multocida fitness and virulence. Using whole-genome sequences, the genotypes, including the capsular genotypes, lipopolysaccharide (LPS) genotypes, and multilocus sequence types, as well as virulence factor-encoding genes of P. multocida isolates from different clinical presentations can be characterized rapidly and accurately. Putative genetic factors that contribute to virulence, fitness, host specificity, and disease predilection can also be identified through comparative genome analysis of different P. multocida isolates. However, although some knowledge about genotypes, fitness, and pathogenesis has been gained from the recent whole-genome sequencing and comparative analysis studies of P. multocida, there is still a long way to go before we fully understand the pathogenic mechanisms of this important zoonotic pathogen. The quality of several available genome sequences is low, as they are assemblies with relatively low coverage, and genomes of P. multocida isolates from some uncommon host species are still limited or lacking. Here, we review recent advances, as well as continuing knowledge gaps, in our understanding of determinants contributing to virulence, fitness, host specificity, disease predilection, and phylogeny of P. multocida.

Original languageEnglish (US)
Article numbere00014-19
JournalMicrobiology and Molecular Biology Reviews
Volume83
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pasteurella multocida
Genomics
Genotype
Genome
Virulence
Host Specificity
Phylogeny
Wild Animals
Domestic Animals
Zoonoses
Virulence Factors
Primates
Lipopolysaccharides

Keywords

  • Comparative genomic analysis
  • Disease predilection
  • Fitness
  • Host specificity
  • Pasteurella multocida
  • Phylogeny
  • Virulence
  • Whole-genome sequencing

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Infectious Diseases

Cite this

Pasteurella multocida : Genotypes and genomics. / Peng, Zhong; Wang, Xiangru; Zhou, Rui; Chen, Huanchun; Wilson, Brenda Anne; Wu, Bin.

In: Microbiology and Molecular Biology Reviews, Vol. 83, No. 4, e00014-19, 01.01.2019.

Research output: Contribution to journalReview article

Peng, Zhong ; Wang, Xiangru ; Zhou, Rui ; Chen, Huanchun ; Wilson, Brenda Anne ; Wu, Bin. / Pasteurella multocida : Genotypes and genomics. In: Microbiology and Molecular Biology Reviews. 2019 ; Vol. 83, No. 4.
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