Partition of Nitrogen Intake and Excretion in Low-Birth-Weight Infants

Sharon M. Donovan, Stephanie A. Atkinson, Bo Lönnerdal

Research output: Contribution to journalArticlepeer-review


Although nitrogen balance studies have been carried out in low-birth-weight infants, few have partitioned the nitrogen into its components. In this study, 72-hour balance studies were conducted in 24 low-birth-weight infants (gestational age, 30.7±1.6 weeks; birth weight 1.36±0.25 kg) fed their mothers’ milk (preterm milk) or 50% preterm milk and 50% formula. Total nitrogen, nonprotein nitrogen, and whey protein intake and excretion were measured. Total nitrogen intake (preterm milk group, 452 ± 138 mg/kg per day; preterm+formula group, 406±93 mg/kg per day), absorption (85%), and retention (71%) were not significantly different between groups. Intact and fragments of secretory IgA and lactoferrin were detected in soluble fecal extracts, and represented 25% and 9% of intake, respectively. Feeding preterm milk allows for nitrogen accretion similar to intrauterine growth rates for 5 weeks postnatally, and provides potentially functional proteins for the low-birth-weight infant.

Original languageEnglish (US)
Pages (from-to)1485-1491
Number of pages7
JournalAmerican Journal of Diseases of Children
Issue number12
StatePublished - Dec 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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