Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Steven R.H. Beach; Man Kit Lei; Gene H. Brody; Sangjin Kim; Allen W. Barton; Meesha V. Dogan; Robert A. Philibert

doi:10.1111/cdev.12486

Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Steven R.H. Beach, Man Kit Lei, Gene H. Brody, Sangjin Kim, Allen W. Barton, Meesha V. Dogan, Robert A. Philibert

Research output: Contribution to journal › Article › peer-review

Abstract

A sample of 398 African American youth, residing in rural counties with high poverty and unemployment, were followed from ages 11 to 19. Protective parenting was associated with better health, whereas elevated socioeconomic status (SES) risk was associated with poorer health at age 19. Genome-wide epigenetic variation assessed in young adulthood (age 19), was associated with both SES risk and protective parenting. Three categories of genes were identified whose methylation was associated with parenting, SES risk, and young adult health. Methylation was a significant mediator of the impact of parenting and SES risk on young adult health. Variation in mononuclear white blood cell types was also examined and controlled, showing that it did not account for observed effects of parenting and SES risk on health.

Original language	English (US)
Pages (from-to)	111-121
Number of pages	11
Journal	Child development
Volume	87
Issue number	1
DOIs	https://doi.org/10.1111/cdev.12486
State	Published - Jan 1 2016
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Education
Developmental and Educational Psychology

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10.1111/cdev.12486

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abstract = "A sample of 398 African American youth, residing in rural counties with high poverty and unemployment, were followed from ages 11 to 19. Protective parenting was associated with better health, whereas elevated socioeconomic status (SES) risk was associated with poorer health at age 19. Genome-wide epigenetic variation assessed in young adulthood (age 19), was associated with both SES risk and protective parenting. Three categories of genes were identified whose methylation was associated with parenting, SES risk, and young adult health. Methylation was a significant mediator of the impact of parenting and SES risk on young adult health. Variation in mononuclear white blood cell types was also examined and controlled, showing that it did not account for observed effects of parenting and SES risk on health.",

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AU - Beach, Steven R.H.

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AU - Brody, Gene H.

AU - Kim, Sangjin

AU - Barton, Allen W.

AU - Dogan, Meesha V.

AU - Philibert, Robert A.

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Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Abstract

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