Paratuberculosis in a Mandrill (Papio Sphinx)

Laura S. Zwick, Timothy F. Walsh, Robyn Barbiers, Michael T. Collins, Michael J. Kinsel, Robert D. Murnane

Research output: Contribution to journalArticlepeer-review


A 2.5-year-old captive female mandrill (Papio sphinx) died following a protracted course of intermittent abdominal bloat, diarrhea, and severe weight loss. Necropsy revealed emaciation and marked gastrointestinal distention with gas and ingesta. Histologic evaluation revealed severe diffuse granulomatous enterocolitis and mesenteric lymphadenitis with massive numbers of 1—2-μm acid-fast bacilli within macrophages. Additionally, there was moderate to severe multifocal myocardial and vascular amyloidosis, moderate multifocal pyogranulomatous interstitial pneumonia with no acid-fast bacteria, and moderate multifocal glossal candidiasis. Samples of feces, ileum, and colon were positive for Mycobacterium avium subsp. paratuberculosis by radiometric culture and a polymerase chain reaction-amplified DNA probe specific for the insertion sequence IS900 of this organism.

Original languageEnglish (US)
Pages (from-to)326-328
Number of pages3
JournalJournal of Veterinary Diagnostic Investigation
Issue number4
StatePublished - Jul 2002

ASJC Scopus subject areas

  • veterinary(all)


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